Based on MapServer layer

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FeatureLayerBasedOnMapServerLayer.mxml

<?xml version="1.0" encoding="utf-8"?>
<s:Application xmlns:fx="http://ns.adobe.com/mxml/2009"
               xmlns:s="library://ns.adobe.com/flex/spark"
               xmlns:esri="http://www.esri.com/2008/ags"
               pageTitle="Example - dynamic maps on top of projected map tiles">
    <!--
    Description:
    This sample demonstrates how a FeatureLayer can be used to enhance the user experience.
    Since the features are client-side, you can enable interactivity through mouse over tooltips
    as well as specifying the symbology client-side.  A FeatureLayer can be used with either a
    map service or feature service, you just reference a specific layer in the service.

    This is similar to the MapCombo.mxml sample where only one layer of a dynamic mapservice is used.
    A major difference is that the dynamic map service creates an image on the server,
    while the FeatureLayer gets the actual feature down to the client.
    This allows for Tooltips and changing the symbols.
    In this example this is accomplished by:
    - a renderer is defined and then used by the FeatureLayer
    - using the graphicAdd on the FeatureLayer to add the tooltips when the features are added (as graphics) to the FeatureLayer.

    Documentation:
    For more information, see the API documentation.
    https://developers.arcgis.com/en/flex/api-reference/com/esri/ags/layers/FeatureLayer.html
    https://developers.arcgis.com/en/flex/api-reference/com/esri/ags/layers/GraphicsLayer.html#event:graphicAdd
    https://developers.arcgis.com/en/flex/api-reference/com/esri/ags/renderers/ClassBreaksRenderer.html
    https://developers.arcgis.com/en/flex/api-reference/com/esri/ags/renderers/supportClasses/ClassBreakInfo.html
    https://developers.arcgis.com/en/flex/api-reference/com/esri/ags/symbols/SimpleMarkerSymbol.html
    -->

    <fx:Style>
        @namespace s "library://ns.adobe.com/flex/spark";
        @namespace esri "http://www.esri.com/2008/ags";
        @namespace mx "library://ns.adobe.com/flex/mx";
        mx|ToolTip
        {
            backgroundColor: #E4342A;
            color: #FFFFFF;
            fontFamily: "Helvetica";
            fontSize: 14;
        }
    </fx:Style>

    <fx:Script>
        <![CDATA[
            import com.esri.ags.events.GraphicEvent;

            protected function featurelayer1_graphicAddHandler(event:GraphicEvent):void
            {
                event.graphic.toolTip = "Population: " + numberFormatter.format(event.graphic.attributes.POP2000);
            }
        ]]>
    </fx:Script>

    <fx:Declarations>
        <s:NumberFormatter id="numberFormatter"/>
        <esri:SimpleMarkerSymbol id="symbol1"
                                 alpha="0.7"
                                 color="0xFF0000"
                                 size="6"
                                 style="triangle"/>
        <esri:SimpleMarkerSymbol id="symbol2"
                                 alpha="0.7"
                                 color="0xFF0000"
                                 size="10"
                                 style="triangle"/>
        <esri:SimpleMarkerSymbol id="symbol3"
                                 alpha="0.7"
                                 color="0xFF0000"
                                 size="16"
                                 style="triangle"/>
        <esri:SimpleMarkerSymbol id="symbol4"
                                 alpha="0.7"
                                 color="0xFF0000"
                                 size="22"
                                 style="triangle"/>
        <esri:SimpleMarkerSymbol id="symbol5"
                                 alpha="0.7"
                                 color="0xFF0000"
                                 size="26"
                                 style="triangle"/>
    </fx:Declarations>

    <s:controlBarContent>
        <s:RichText width="100%">
            This sample demonstrates how a FeatureLayer can be used to enhance the user experience.
            Since the features are client-side, you can enable interactivity through mouse over tooltips
            as well as specifying the symbology client-side.  A FeatureLayer can be used with either a
            map service or feature service, you just reference a specific layer in the service.
            This map combines a tiled street map with a FeatureLayer service showing census block points rendered using a class break renderer.
        </s:RichText>
    </s:controlBarContent>

    <esri:Map>
        <esri:extent>
            <esri:Extent id="lowerManhattan"
                         xmin="-8239000" ymin="4968000" xmax="-8235000" ymax="4971000">
                <esri:SpatialReference wkid="102100"/>
            </esri:Extent>
        </esri:extent>
        <esri:ArcGISTiledMapServiceLayer url="http://server.arcgisonline.com/ArcGIS/rest/services/World_Street_Map/MapServer"/>
        <esri:FeatureLayer graphicAdd="featurelayer1_graphicAddHandler(event)"
                           outFields="[FIPS,POP2000]"
                           url="http://sampleserver1.arcgisonline.com/ArcGIS/rest/services/Demographics/ESRI_Census_USA/MapServer/0">
            <esri:renderer>
                <esri:ClassBreaksRenderer field="POP2000">
                    <esri:ClassBreakInfo maxValue="61" symbol="{symbol1}"/>
                    <esri:ClassBreakInfo maxValue="264"
                                         minValue="62"
                                         symbol="{symbol2}"/>
                    <esri:ClassBreakInfo maxValue="759"
                                         minValue="265"
                                         symbol="{symbol3}"/>
                    <esri:ClassBreakInfo maxValue="1900"
                                         minValue="760"
                                         symbol="{symbol4}"/>
                    <esri:ClassBreakInfo minValue="1901" symbol="{symbol5}"/>
                </esri:ClassBreaksRenderer>
            </esri:renderer>
        </esri:FeatureLayer>
    </esri:Map>
</s:Application>