You can perform detailed spatial queries on feature layer attributes.
<!DOCTYPE html>
<html lang="en">
  <head>
    <meta charset="utf-8">
    <title>Perform a spatial query</title>
    <meta name="viewport" content="initial-scale=1, maximum-scale=1, user-scalable=no">
    <link rel="stylesheet" href="https://unpkg.com/leaflet@1.9.4/dist/leaflet.css"
      crossorigin="">
    <script src="https://unpkg.com/leaflet@1.9.4/dist/leaflet.js"
      crossorigin=""></script>
    <!-- Load Esri Leaflet from CDN -->
    <script src="https://unpkg.com/esri-leaflet@3.0.19/dist/esri-leaflet.js"></script>
    <!-- Load Esri Leaflet Vector from CDN -->
    <script src="https://unpkg.com/esri-leaflet-vector@4.3.2/dist/esri-leaflet-vector.js" crossorigin=""></script>
    <style>
      html,
      body,
      #map {
        padding: 0;
        margin: 0;
        height: 100%;
        width: 100%;
        font-family: Arial, Helvetica, sans-serif;
        font-size: 14px;
        color: #323232;
      }
      #panel {
        position: absolute;
        top: 10px;
        right: 10px;
        z-index: 1000;
        background: white;
        padding: 10px;
      }
    </style>
  </head>
  <body>
    <div id="map"></div>
    <div id="panel" class="leaflet-bar">
      Neighborhoods
      <select name="relation" id="relationSelect">
        <option value="within">Within</option>
        <option value="contains">Contains</option>
        <option value="intersects">Intersects</option>
        <option value="overlaps">Overlaps</option>
      </select>
      <select name="geometry" id="geometrySelect">
        <option value="bounds">Bounds</option>
        <option value="point">Point</option>
        <option value="line">Line</option>
        <option value="polygon">Polygon</option>
      </select>
      <button id="executeQuery">Run Query</button>
    </div>
    <script>
      const accessToken = "YOUR_ACCESS_TOKEN";
      const map = L.map("map").setView([45.525, -122.628], 11);
      L.esri.Vector.vectorBasemapLayer("arcgis/outdoor", {
        token: accessToken
      }).addTo(map);
      const neighborhoods = L.esri.featureLayer({
        url: "https://www.portlandmaps.com/arcgis/rest/services/Public/Zoning/MapServer/32",
        style: {
          color: "#000",
          weight: 1,
          opacity: 0.4
        }
      }).addTo(map);
      const marker = L.marker([45.571034, -122.686386]).addTo(map); // Create a marker object to query against
      const bounds = L.latLngBounds([ // Create a bounds object to query against
        [45.494556, -122.691536],
        [45.538100, -122.608452]
      ]);
      L.rectangle(bounds, { // Create a rectangle to visualize the bounds
        color: "blue",
        weight: 2
      }).addTo(map);
      const line = L.polyline([ // Create a line to query against
        [45.559256, -122.611885],
        [45.502256, -122.562790],
        [45.483244, -122.620468]
      ], {
        color: "blue",
        weight: 2
      }).addTo(map);
      const polygon = L.polygon([ // Create a polygon to query against
        [45.484894, -122.493696],
        [45.512025, -122.492199],
        [45.517669, -122.561457],
        [45.487343, -122.558573]
      ], {
        color: "blue",
        weight: 2
      }).addTo(map);
      const geometries = {
        bounds: bounds,
        line: line,
        polygon: polygon,
        point: marker
      };
      const relationship = document.getElementById("relationSelect");
      const geometry = document.getElementById("geometrySelect");
      const runQueryButton = document.getElementById("executeQuery");
      let previousIds = [];
      function reset() { // Reset all features back to their regularly defined styles
        for (let i = previousIds.length - 1; i >= 0; i--) {
          neighborhoods.resetStyle(previousIds[i]);
        }
      }
      function query() {
        reset();
        const inputGeometry = geometries[geometry.value];
        neighborhoods.query()[relationship.value](inputGeometry).ids(function (error, ids) {
          if (error) {
            console.log("Error with query: " + error);
          } else if (ids) {
            previousIds = ids;
            for (let i = ids.length - 1; i >= 0; i--) {
              neighborhoods.setFeatureStyle(ids[i], { color: "red", weight: 2 });
            }
          }
        });
      }
      runQueryButton.addEventListener("click", query);
      neighborhoods.once("load", function () {
        query();
      });
    </script>
  </body>
</html>